Even in the relatively peaceful ComEmp period there were occasional incidents leading to loss of life. Leaving in 5201, the G995 was a very large (3 kg) starwisp used to ferry small numbers of copied intellects between systems in a region that distrusted cold- storage of intellects. Thus, the minds in question had to remain 'conscious' and active during the trip, and the huge starwisp carried only a few (<100) baseline intellects on its journeys.
During a scheduled 4-lightyear transit, G995 was knocked off course by an unexpected 'gust' from a nearby pulsar, as orbital mechanics freakishly lined things up. The ship eventually deviated by roughly a hundredth of a light-year at the terminal end, which was disastrous, as its onboard transmission capabilities were of light-minute range.
The minds onboard the ship were made aware of the problem via the semi-sentient virch interface to the control nodes of ship, and tumult ensued (according to the "black box" recorders later retrieved.)
The virch's hardcoded limitations prevented suicide by those in transit, and also prevented any time-distortion effects, it being an article of faith for the societies in question that minds should work at one second per second lest there be a dis-associative effect inside the culture.
As a few minds found new methods of suicide, the wispmind closed the avenues off as it had been designed to do. The remaining travelers were consigned to a very long trip with no hope of rescue through the dark between the stars. A small group continued to spend significant amounts of energy on transmissions, 'Just In Case' someone was close enough to hear them. Others were nigh catatonic; some entered deep denial, and yet others resented the power wastage spent on the transmissions, seeing it as a reduction of their lifespan in their reduced situation.
The pro- and anti-transmission factions struggled for control of the wispmind, both convinced of their correctness. It was eventually discovered that, although the wispmind prevented suicidal activities, it did not protect itself to the same degree. The anti- transmission faction (who termed themselves the 'life-savers') used this to cripple the wispmind and destroy its capability to transmit.
Later investigators found this sadly ironic, as there were several craft that passed within light-minutes of the vessel in the centuries of its wanderings, and once the wisp was even deflected by the side scatter of a ship passing within light-seconds.
Eventually, three hundred and twenty eight years after launch, the starwisp was detected by a warship in transit. The warship had enough delta-v capacity to maneuver to pick up the derelict craft, and did so. By this time, there were no intact intellects left on the vessel, and the centuries-long log depicted a hellacious experience of struggle against the inner demons of sentience.
It remains a highly cited work regarding the nature of sophonce in many different polities and philosophies. Of course, the conclusions reached based on the logs differ wildly from place to place and time to time.