Are we canonically dead?

[Rynn]

On the subject, what's the earliest period a preserved (including effective brain preservation and uploading) modosophont still living or existing in cold storage in 10601 AT could theorically be from?

Theoretically around 400a.t. This was the period when uploading was first attempted, but it wasn't successful because of errors in the emulation software (mostly due to lack of knowledge). The minds that were ran slowly succumb to a variety of neurodegenerative diseases which is what led to a ban on uploading at the time. The data for each person scanned was kept however. It's unlikely any would have survived the technocalypse, but possible.

https://www.orionsarm.com/eg-article/48bda472970cb